Castañeta G., Villagomez R., Salamanca E., Canaviri-Paz P., Bravo J.A., Vila J.L., Bárcenas-Pérez D., Cheel J., Sepúlveda B., Giménez A. & Areche C.
Microwave-assisted semisynthesis and leishmanicidal activity of some phenolic constituents from lichens
10(10): 524 [15 p.]
Leishmaniasis is considered one of the most untreated tropical diseases in the world. In this study, we investigated the in vitro leishmanicidal activity and cytotoxicity of various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric acid (3), salazinic acid (4), galbinic acid (5), and parietin (6), and some semi-synthetic imine derivatives of usnic acid (7, 8, 9) and atranorin (10, 11, 12, 13). Imine condensation reactions with hydrazine and several amines were assisted …