Varlı M., Bhosle S.R., Jo E., Yu Y.H., Yang Y., Ha H.-H. & Kim H.
(2025):
Development and synthesis of diffractaic acid analogs as potent inhibitors of colorectal cancer stem cell traits,
Scientific Reports,
15: 6695 [20 p.]
In recent years, evidence for the anti-cancer activity of lichen secondary metabolites has been rapidly
increasing. In this study, we synthesised analogues of diffractaic acid, a lichen secondary metabolite,
and evaluated their ability to suppress colorectal cancer stem potential. Among the 10 compounds
after H/CH₃/benzylation of the diffractaic acid structure or modifications in an aromatic hydrophobic
domain, TU3 has a more inhibition effect on the stem potential of colorectal cancer …
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