- Nguyen T.-Q.-T., Pham N.-K.-T., Trung N.T., An T.N., Mai D.-T., Sichaem J., Huynh B.-L.-C., Anh N.T.H., Nguyen N.-H. & Duong T.-H.
- Natural Product Research
- 37(8): 1284‒1291
One new hopane-type triterpene, indicuen (1), along with eight known compounds (2–9) were isolated from the n-hexane extract of the lichen Parmotrema indicum Hale. The chemical structures of isolated compounds were identified by interpretation of their spectroscopic data (1D, 2D NMR and HRESIMS) combined with DFT-NMR chemical shift calculations and subsequent assignment of DP4+ probabilities and by comparison with the literature. Indicuen represents for a rare hopane bearing a 1-carboxyethyl substituent at C-21 in lichens. Compounds 1–3 and 5–8 were evaluated for α-glucosidase inhibition and cytotoxicity against K562 and HepG2 cancer cell lines. Compounds 1, 5 and 7 exhibited moderate α-glucosidase inhibition with IC50 values of 201.1, 156.3 and 187.4 µM, respectively. Compound 1 also showed weak cytotoxicity toward K562 cell line while others showed no activity.
Keywords: Lichen; Parmotrema indicum
Hale; indicuen; triterpene;
- Saturday, 05 August 2023 18:07