A new phthalazinone derivative and a new isoflavonoid glycoside from lichen-associated Amycolatopsis sp.
- Author:
- Zheng K.-X., Jiang Y., Jiang J.-X., Huang R., He J. & Wu S.-H.
- Year:
- 2019
- Journal:
- Fitoterapia
- Pages:
- 135: 85–89
- Url:
- https://doi.org/10.1016/j.fitote.2019.04.011
A new phthalazinone derivative, named amycophthalazinone A (1), and a new isoflavonoid glycoside, 7-Omethyl-
5-O-α-L-rhamnopyranosylgenestein (2), along with an isoflavonoid glycoside, 7-O-α-D-arabinofuranosyl
daidzein (3) firstly found from natural sources, and eight known compounds (4–11), were isolated from the
culture broth of the lichen-associated Amycolatopsis sp. YIM 130642. The structures of new compounds were
elucidated on the basis of spectroscopic analysis. Compound 1 was the first example of naturally occurring
phthalazinone derivative. The antimicrobial activities of all compounds towards five pathogenic strains were
evaluated by a broth microdilution assay. Compound 1 exhibited the most potent inhibitory activity against
Staphylococcus aureus, Salmonella typhi, and Candida albicans with MIC values of 32, 32, and 64 μg/mL, respectively.
Keywords: Amycolatopsis; Lichen; Phthalazinone; Isoflavonoid; Antimicrobial activity.
- Id:
- 32810
- Submitter:
- zdenek
- Post_time:
- Monday, 12 October 2020 17:12