Yu X., Sui Y., Xi Y., Zhang Y., Luo G., Long Y. & Yang W.
(2023):
Semisynthesis, biological evaluation and molecular docking studies of barbatic acid derivatives as novel diuretic candidates,
Molecules,
28(10): 4010 [20 p.]
Barbatic acid, a compound isolated from lichen, has demonstrated a variety of biological activities. In this study, a series of esters based on barbatic acid (6a–q′) were designed, synthesized, and evaluated for their diuretic and litholytic activity at a concentration of 100 μmol/L in vitro. All target compounds were characterized using 1H NMR, 13C NMR, and HRMS, and the spatial structure of compound 6w was confirmed using X-ray crystallography. The biological results showed that some derivatives, …
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