The Klamath region is known for diverse climate, topography, and geology, as well as a very long floristic history. The many endemic vascular plants of the region reflect these unusual qualities. Given the variety of terrestrial and epiphytic habitats, a diverse lichen flora should be expected. Although several rare lichens are known from the region, no endemic lichen taxa have been found. However, the lichen flora of the Klamath region is poorly known; lichens endemic to the region may exist, but have not yet been found. Saxicolous and terricolous lichens are often influenced by substrate chemistry, so the peculiar chemistry of ultramafic substrates that occupy large portions of the Klamath region may support unusual lichen communities. Several lichens have interesting distributions with relevance to the Klamath region. A large population of Bryoria tortuosa, a rare species in the Pacific Northwest, is located in the Klamath region. Umbilicaria phaea var. coccinea is a taxon that is close to being a Klamath region endemic. During the Siskiyou Conference on Ecology and the associated field trips, several interesting discoveries were made. These include a fourth population for the globally rare lichen Sulcaria badia, and two species not previously reported for California (Umbilicaria lambii and Umbilicaria rigida). A prehumy checklist to the lichens of the Klamath region, including 83 genera and 218 species, was assembled from the 3 lichen floristic reports available for the area and the author's collection.