Salazinic acid and norlobaridone from the lichen Hypotrachyna cirrhata: Antioxidant activity, α-glucosidase inhibitory and molecular docking studies

Author:
Kumar T.K., Siva B., Kiranmai B., Alli V.J., Jadav S.S., Reddy A.M., Boustie J., Le Devehat F., Tiwari A.K. & Suresh Babu K.
Year:
2023
Journal:
Molecules
Pages:
28(23): 7840 [20 p.]
Url:
https://doi.org/10.3390/molecules28237840
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The present study was intended for the identification of secondary metabolites in acetone extract of the lichen Hypotrachyna cirrhata using UPLC-ESI-QToF-MS/MS and the detection of bioactive compounds. This study led to the identification of 22 metabolites based on their MS/MS spectra, accurate molecular masses, molecular formula from a comparison of the literature database (DNP), and fragmentation patterns. In addition, potent antioxidant and α-glucosidase inhibitory potentials of acetone extract of H. cirrhata motivated us to isolate 10 metabolites, which were characterized as salazinic acid (11), norlobaridone (12), atranorin (13), lecanoric acid (14), lichesterinic acid (15), protolichesterinic acid (16), methyl hematommate (17), iso-rhizonic acid (18), atranol (19), and methylatratate (20) based on their spectral data. All these isolates were assessed for their free radicals scavenging, radical-induced DNA damage, and intestinal α-glucosidase inhibitory activities. The results indicated that norlobaridone (12), lecanoric acid (14), methyl hematommate (17), and atranol (19) showed potent antioxidant activity, while depsidones (salazinic acid (11), norlobaridone (12)) and a monophenolic compound (iso-rhizonic acid, (18)) displayed significant intestinal α-glucosidase inhibitory activities (p
Id:
35958
Submitter:
zpalice
Post_time:
Wednesday, 29 November 2023 22:03